Spinal High-Velocity Low Amplitude Manipulation in Acute Nonspecific Low Back Pain: A Double-Blinded Randomized Controlled Trial in Comparison With Diclofenac and Placebo
Spine, April 2013;38(7):540-48.
Von Heymann, Wolfgang J. Dr. Med*; Schloemer, Patrick Dipl. Math†; Timm, Juergen Dr. RER, NAT, PhD†; Muehlbauer, Bernd Dr. Med*
A recent article in Spine Journal, one of the most renown Scientific Journals for Spinal Disorders, compared the effects of Spinal Manipulation, high velocity low amplitude thrust, vs. Diclofenac in a Double Blinded RCT.
Diclofenac is a common NSAID (non-steroidal Anti-inflammatory) drug taken to reduce inflammation and as an analgesic.
A total of 101 patients with acute low back pain, defined as less than 48 hours in duration, were recruited from 5 outpatient clinics. The subjects were randomized to 3 groups: (1) spinal manipulation and placebo-diclofenac; (2) sham manipulation and diclofenac; (3) sham manipulation and placebo-diclofenac.
Thirty-seven subjects received spinal manipulation, 38 diclofenac, and 25 no active treatment. The placebo group with a high number of dropouts for unsustainable pain was closed praecox. Comparing the 2 active arms with the placebo group the intervention groups were significantly superior to the control group. Ninety subjects were analyzed in the collective intention to treat. Comparing the 2 intervention groups, the manipulation group was significantly better than the diclofenac group (Mann-Whitney test: P = 0.0134). No adverse effects or harm was registered.
Conclusion. In a subgroup of patients with acute nonspecific LBP, spinal manipulation was significantly better than nonsteroidal anti-inflammatory drug diclofenac and clinically superior to placebo.
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